Trulance is the only structural analog of human uroguanylin and is believed to replicate the pH-sensitive activity of uroguanylin1-6
Uroguanylin activity modulates within the changing pH environment of the intestines, coinciding with areas of fluid secretion, and decreases pain sensation1,6-8
Uroguanylin stimulates fluid secretion, thereby maintaining stool consistency necessary for regular bowel function1,6
Based on pre-clinical studies. Clinical relevance of this data has not been established.
1ACTIVATES GC-C receptors in a pH-sensitive manner6
2Increases cGMP and regulates electrolyte homeostasis5
3Stimulates fluid secretion and facilitates bowel movements2
4Decreases the activity of pain-sensing nerves in the intestine7,8